Title of Document : ANTIOXIDANT AND ANTI - PROLIFERATIVE PROPERTIES OF SELECTED GRAPE SEED EXTRACTS
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چکیده
Title of Document: ANTIOXIDANT AND ANTIPROLIFERATIVE PROPERTIES OF SELECTED GRAPE SEED EXTRACTS Raquel Zorah Bloom, Master of Science, 2009 Directed By: Associate Professor Dr. Liangli Yu Nutrition and Food Science This study examined chardonnay, muscadine, concord, and ruby red grape seed oil and flour extracts for antioxidant and anti-proliferative properties. The extracts were tested for total phenolic content, DPPH and ABTS radical scavenging capacity and effect against HT-29 cancer cell proliferation. All of the grape seed extracts exhibited ABTS and DPPH radical quenching activity. The flour extracts from chardonnay demonstrated the highest ABTS radical quenching capacity of 186 μmoles trolox equivalents/g and DPPH radical quenching activity of 30 μmoles trolox equivalents/g. All of the grape seed oil and flour extracts contained significant levels of phenolics. Chardonnay grape seed flour extract displayed the most prominent dose dependent anti-proliferative effect. Muscadine and ruby red, but not concord grape seed flour extracts, also exhibited anti-proliferative activities. The collected data advocate for the potential of grape seed extracts as dietary sources of anti-proliferative and antioxidant components. ANTIOXIDANT AND ANTI-PROLIFERATIVE PROPERTIES OF SELECTED GRAPE SEED EXTRACTS
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